There are plenty of media reports about exciting advances in medicine. But those same outlets seem to go silent when what had initially appeared to be a breakthrough fails the next round of studies. It happens surprisingly often. This becomes a problem when practioners don't keep up with current research. They may continue to use older treatments or procedures, even after those interventions have been shown to be ineffective or even harmful. The Mayo Foundation for Medical Education and Research recently set out to address this problem. Their team, led by Dr. Vinay Prasad, looked at ten years of research articles published in a top journal to examine how many of the treatments, procedures, tests, surgeries, screenings, medications or other interventions in use today have truly been shown to work. Only 38% of articles evaluating established treatments found them to be beneficial. More than 40% of the published studies looking at an established treatment found it to be no better than or worse than the standard practice. To be clear, this doesn’t mean that 40% of procedures were ineffective. It means that in 40% of the studies reviewed, earlier positive results were superseded by later studies that reversed initial findings. To disprove earlier work a new study had to be more rigorously designed, better powered or better controlled.
Here are some of the practices that didn't pass that second look:
2) The use of mite-allergen impermeable mattress pads and pillow covers to prevent asthma in adults. A double-blind, placebo-controlled and randomized study done in 2003 found this type of bedding had no impact on asthma symptoms.
3) Aggressive control of blood sugar to prevent heart disease. A large 2008 study found that intensive glucose lowering in diabetics actually increased mortality and did not prevent cardiac problems. Adhering to more permissive glucose targets gave patients better outcomes.
4) Naltrexone to treat alcoholism. A multi-center, randomized and placebo-controlled study failed to find that naltrexone, an opioid-receptor antagonist, added any benefit to standard psychosocial treatment.
5) Antibiotics for asymptomatic UTIs in diabetic women. In 2002 a randomized trial found that antibiotics did not reduce diabetic women’s time to symptomatic infection, or the number of complications due to urinary tract infections.
6) Arthroscopic surgery for osteoarthritis of the knee. Two controlled studies failed to find benefit from this procedure.
7) Hypothermia during aneurysm surgery. The Intraoperative Hypothermia for Aneurysm Surgery Trial (IHAST) found in 2005 that cooling patients during neurosurgery for aneurysm provided no post-operative neurologic benefit.
8) High-dose chemotherapy with autologous stem-cell transplants for high-risk breast cancer. Even though this procedure reduced cancer relapse rates in the affected breast/axillary area , a randomized trial failed to find that it increased survival rates compared to conventional adjuvant chemotherapy.
9) Preimplantation genetic screening for IVF. Genetic screening during in vitro fertilization for women of advanced maternal age was studied in a multicenter, double-blind study. The researchers concluded that preimplantation genetic screening actually reduced the number of pregnancies and live births.
10) Inserting stents in patients with coronary artery infarction. In a randomized trial of people who had suffered total blockage of an artery (myocardial infarction), patients were randomly assigned to a group who received either optimal medical therapy or optimal medical therapy with stents. The stented group did no better in terms of survival rate, reinfarction or heart failure.
Read the Study: A Decade of Reversal: An Analysis of 146 Contradicted Medical Practices
By Vinay Prasad,MD; Andrae Vandross, MD; Caitlin Toomey, MD; Michael Cheung, MD; Fason Rho, MD; Steven Quinn,MD; Jacob Chacko, MD; Durga Bonkar, MD; Victor Gall, MD; Senthil Selvaraj, MD; Nancy Ho, MD; and Adam Cifu, MD